SPARC Plenary Talk – Neuromodulation and Robustness to Perturbation of a Rhythmic Circuit
Eve Marder PhD Professor of Biology, Brandeis University, Waltham, MA, USA
Marc Kaufman, Ph.D.
For the past thirty years my research has focused on the neural mechanisms that control the circulation during exercise. I have paid particular attention to one of these mechanisms, namely the exercise pressor reflex, which is evoked by metabolic and mechanical stimuli arising in exercising skeletal muscles and whose sensory arm is comprised of group III and IV afferents. Currently, we are investigating the exercise pressor reflex in rats whose hindlimb muscles are either freely perfused or have had their femoral arteries ligated. In both preparations, we focus on determining the responses of the group III and IV afferents to contraction before and after activation and inactivation of EP4, TP, IP, purinergic 2X, and ASIC 3 receptors.
Jeffrey L. Ardell, Ph.D. FAHA
Professor of Medicine/Cardiology; Professor of Anesthesiology
Director, Neurocardiology Research Program of Excellence
Co-Director, UCLA Cardiac Arrhythmia Center
Research Faculty, Molecular, Cellular and Integrative Physiology
Dr. Ardell is the founding Director of the UCLA Neurocardiology Research Program of Excellence (established 2014). He is a Professor of Medicine, David Geffen School of Medicine at UCLA, and is recognized as one of the founding fathers of the field of neurocardiology. The aim of Dr. Ardell’s research is to develop novel neuromodulation based therapies to mitigate the adverse remodeling of the heart and cardiac nervous system that result from cardiac disease. Dr. Ardell received his bachelor’s degree from Colorado College and his Ph.D. from the University of Washington in Seattle. He completed his postdoctoral training at Michigan State University and Loyola University Chicago. He was a Professor in the Department of Physiology at the University of South Alabama, and then served as Professor of Pharmacology and Vice Chairman for Research at the Quillen College of Medicine—East Tennessee State University. Dr Ardell was honored as an Established Investigator of the American Heart Association, and was elected as a fellow of the American Heart Association in 1993. He serves as peer reviewer for several basic science journals in cardiovascular sciences. His work has received continuous extramural funding since 1984 made possible by several grants from the American Heart Association, National Institutes of Health and in collaboration with multiple private companies.
John Furness PhD FAA FAHMS
Professor John Furness leads the Digestive Physiology and Nutrition Laboratory at the Florey Institute of Neuroscience and Mental Health and the University of Melbourne, where he has appointments in the Medical and Veterinary and Agricultural Sciences Faculties.
He is best known for his work in unravelling the intrinsic circuits of the enteric nervous system, for the chemical coding hypothesis, and for the discovery and identification of sensory neurons intrinsic to the digestive tract.
The current emphases of his work are on (i) the relationships between diet, environment and gut health, and their implications for animal production and for human well-being; (ii) the influence on gut function of neuromodulatory therapies and their applicability to treatment of inflammatory bowel disease and gastroparesis; and (iii) the complexities of co-storage of gut endocrine hormones. He has worked closely with the pharmaceutical, medical devices and animal production industries.
He is one of the most highly cited Australian scientists. Google Scholar (January 2019) gives his h-index as 107, including 40,400 citations overall.
Honours and Awards include:
Fellow of the Australian Academy of Science, 1989
Fellow, Academy of Science of Bologna (L'accademia delle scienze dell'istituto di Bologna), the second oldest scientific academy in existence, 2005
Centenary Medal, Govt of Australia, 2003
Fellow of the Australian Academy of Health and Medical Sciences, 2017